Year-end Sale % OFF 
Abstract
The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyrosinase with N-aminoethylethanolamine to produce Cu(II)-NPs and these were characterized by means of FT-IR, UV-Spectroscopy, XRD, SEM, TEM and a particle size analyzer. These Tyr-Cu(II)-AEEA NPs were tested as anticancer agents against MCF-7 breast cancer cells. Fluorescence microscopy and DNA fragmentation were also performed, which revealed the inhibiting potentials of Cu(II)-AEEA NPs and consequent cell death; Tyr-Cu(II)-AEEA NPs show potential cytotoxicity activity and this nano material could be contemplated as an anticancer medicament in future investigations.
Highlights
In recent years, nanotechnology has become a promising research field and its current focus on medicine and nanoparticles (NPs) has an immense scientific attraction in the context of biological screening
The synthesis of bis-(N-aminoethylethanolamine)-Copper(II) nanoparticles (Cu(II)AEEA NPs) and the reaction outline are represented in Scheme 1
The tyrosinase was mixed with ligand 2-((2-aminoethyl)amino)ethanol at room temperature
Summary
Nanotechnology has become a promising research field and its current focus on medicine and nanoparticles (NPs) has an immense scientific attraction in the context of biological screening. The cases of cancer are enhanced due to various factors and the World Health Organization (WHO) reported that the incidence of cancer increased from the year 2008 and it reaches above 12.7 million, which is equivalent to 25 million per year [1]. In this emergency situation, several researchers are working in this area, but the exact causes have not been identified and there exists the need for novel anticancer drugs with zero side effects. They can cause inflammations and fibrosis in multicellular organisms and cytotoxicity in unicellular beings
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
