Abstract
1. 1. Potassium-selective channels were analysed in growth cones of cultured leech Retzius cells. 2. 2. In the cell-attached mode and at physiological bath and pipette solution little channel activity was observed at resting membrane potential. The channel open probability ( p o ) increased with cell depolarization, and the slope conductance of the single K + channel current was about 60 pS. 3. 3. With symmetrical high KCl solution on both sides of the excised membrane patch three K + -selective channels could be discriminated. Two channels exhibited a linear current-voltage relation of about 18 pS and 106 pS, respectively. 4. 4. The most frequently observed K + channel showed a non-linear current-voltage relation and p o increased with increasing free cytoplasmic Ca 2+ and during cell hyperpolarization.
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