Abstract
G-protein coupled receptors (GPCRs) and the large-conductance, voltage- and Ca2+ -activated K+ channel (MaxiK), are commonly expressed at the plasma membrane of cells. GPCR activation results in activation or inhibition of MaxiK channel activity depending on the type of GPCR. For example, activation of Thromboxane A2 receptor leads to MaxiK channel inhibition. We now investigate whether MaxiK channel alpha subunit (Slo1) can talk back and regulate Thromboxane A2 receptor (TP) function. To this end, we analyzed two downstream processes of activated TP: activation of the monomeric G-protein Rho and stimulation of intracellular calcium release.
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