Abstract
Novel unsymmetrical Schiff bases (L3a-L3c) were synthesized by using a two-stage method. The starting Schiff bases were prepared by the reaction of 2-aminophenol (or 2-amino-4-methylphenol or 2-amino-4-chlorophenol) with 1-nitro-2-naphthaldehyde. In these compounds, the nitro groups were reduced to amino groups using selective reducing agent and then 2-hydroxybenzaldehyde were added. Thus, three new unsymmetric Schiff base ligands were obtained. The antimicrobial activity of the synthesized unsymmetric Schiff bases were evaluated against some pathogenic strains (Shigella dysenteria type 7, Listeria monocytogenes 4b, Escherichia coli, Salmonella typhi H, Staphylococcus epidermis, Brucella abortus, Micrococcus luteus, Bacillus cereus sp., Pseudomonas putida sp.) and yeast (Candida albicans).
Highlights
Schiff bases contain azomethine groups (-CH=N-) and are synthesized from condensation between amines and active carbonyl compounds
Pathogenic bacterial cultures and yeast were tested for resistance to five antibiotics: kanamycin (it is bactericidal against gram negative bacteria and gram-positive bacteria and are indicated for the treatment of infections that are susceptible to microorganisms sensitive gram (-) and gram (+) are indicated), sulphamethoxazol, ampicillin (bactericidal that inhibit the growth of gram (-) bacteria), amoxicillin (it is a penicillin effective against gram (+) and gram (-) bacteria and is a broad spectrum antibiotic), nystatin
All ligands (L3aL3c) show more antifungal activity against C. albicans than commercial antifungal
Summary
Schiff bases contain azomethine groups (-CH=N-) and are synthesized from condensation between amines and active carbonyl compounds. Schiff bases ligands and their complexes have many biochemical, clinical, pharmacological and biological properties [8,9,10]. They show a broad range activities including antimalarial, antibacterial, antiviral, antitumor, antifungal, antimicrobial, antiinflammatory, antioxidant, anticancer, antidiabetic, antiproliferative, antipyretic properties, analgesic and anti-HIV properties [11,12,13,14,15,16,17,18]. There are few studies on (–CH=N-aryl-CH=N–) type unsymmetrical Schiff bases due to the fact that they cannot be synthesized directly. The biological activities of all unsymmetrical Schiff bases against some bacteria and yeast strains are examined
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