Abstract
Twenty-nine volunteers participated in a randomized, double-blind, placebo-controlled study. Cerebral blood velocity (CBV), pulse rate, blood pressure (BP), skin perfusion (SP) on forehead and plasma Δ 9 tetrahydrocannabinol (THC) levels were quantified during reclining and standing for 10 min before and after THC infusions and marijuana smoking. Both THC and marijuana induced postural dizziness, with 28% reporting severe symptoms. Intoxication and dizziness peaked immediately after drug. The severe dizziness group showed the most marked postural drop in CBV and BP and showed a drop in pulse rate after an initial increase during standing. Postural dizziness was unrelated to plasma levels of THC and other indices.
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