Abstract
The transcriptional activity of tubulin genes during synaptogenesis in developing rat brain has been examined by ‘nuclear run off assay’. For both α and β tubulin genes, the relative rates of transcription were found to be high during the early phase of synaptogenesis (postnatal days 1–5) and declined 20–50% by the end of synaptogenesis (postnatal days 15–20). Comparison of the developmental alterations in the rates of transcription of both α and β tubulin mRNA with the level of polysomal tubulin mRNA shows that the age related decline (70–80%) in the level of polysomal tubulin mRNA during synaptogenesis is much too large compared to the 20–25% decline in their transcription rates suggesting that tubulin mRNA levels in developing rat brain are regulated post-transcriptionally.
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