Abstract
Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology
Highlights
Following the completion of the human genome sequence and the concomitant technological innovations required for whole genome analyses, the last decade has witnessed an explosion of data and information concerning the posttranscriptional regulation of gene expression, in both pathological and nonpathological contexts
Among the most notable posttranscriptional events studied are the widespread usage of alternative splicing, the pleiotropic regulatory roles of miRNAs, and breakthroughs in the understanding of the control of gene expression by noncoding RNA transcripts
In this special issue of this journal, the spotlight is centered on the role that various mechanisms of posttranscriptional regulation—and the RNA binding proteins (RBPs) that control them—play in cancer biology
Summary
Adaptive changes in gene expression programs are crucial during tumor development, in order to allow cancer cells to support growth, survival, and metastasis and to resist to therapeutic treatments. Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology Claudia Ghigna,[1] Luca Cartegni,[2] Peter Jordan,[3] and Maria Paola Paronetto[4,5]
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