Abstract
Post-stroke fatigue (PSF) is a common, long-lasting consequence of acute cerebrovascular events (ACE). Aim. To assess the rate and intensity of PSF over the second year after strokes and transient ischemic attacks. Material and methods. Initially patients were followed up and examined in 12 months (201 cases) and finally in 24 months (126 cases) after ACE occurrence; through these time intervals patients were examined quarterly. PSF was measured by fatigue assessment scale (FAS), multidimensional fatigue inventory-20 (MFI-20) and fatigue severity scale (FSS). Results. According to FAS and FSS, rate of PSF over the second year after ACE occurrence were unchangeable within narrow limits, 31,7%-33,0%. Rates of global, physical, mental, activity-related and motivational post-stroke fatigue, according to MFI-20, were also stable, within 25,0%-28,6%, 24,6%-27,4%, 27,8%-30,2%, 22,4%-26,2% and 19,4%-22,0%, respectively. Patients with strokes, compared with transient ischemic attack patients, had more common general, physical, mental, motivational and activity-related post-stroke fatigue domains in 12 and 15 months after ACE occurrence. Intensity of PSF due to FAS (range – 29,0 (26,0-33,0) – 28,0 (26,0-32,2)) and FSS (5,5 (5,2-5,9) – 4,8 (4,5-5,2)), as well as intensity of physical (13,0 (12,0-13,0) – 12,0 (12,0-13,0)) and activity-related (13,0 (12,0-13,0) – 12,0 (12,0-13,5)) PSF domains due to MFI-20, was statistically stable, whereas severity of global (14,0 (13,0-15,0) – 13,0 (12,0-14,0)), mental (15,0 (14,0-16,0) – 13,0 (12,0-14,0)) and motivational (15,0 (14,0-16,0) – 13,0 (13,0-15,0)) PSF domains significantly decreased through the second year after ACE. Conclusion. 1. PSF rate as well as PSF dimension rates were stable over the second year after ACE regardless the fatigue scales used. 2. Intensity of gobal, mental and motivational post-stroke fatigue domains, according to MFI-20, significantly decreased over the second year after ACE occurrence.
Highlights
Nowadays, as the consequence of the crucial lifestyle modification and environmental factor changes we face a dramatic increase of civilization diseases and their complications, including cerebrovascular events [1]
Table 1 shows no differences in Post-stroke fatigue (PSF) rates, according to fatigue assessment scale (FAS), as well as according to fatigue severity scale (FSS), over the whole second year after acute cerebrovascular events (ACE) occurrence
Cochran’s Qtest of those patients who were observed through all five studied time points did not reveal any significant differences of PSF rates obtained by both fatigue scales
Summary
As the consequence of the crucial lifestyle modification and environmental factor changes we face a dramatic increase of civilization diseases and their complications, including cerebrovascular events [1]. Post-stroke fatigue (PSF) is a common and often debilitating complication of acute cerebrovascular events (ACE) [2]. In our previous work we revealed that PSF rate significantly changed over the first three post-stroke months and was statistically stable over the nine months after stroke occurrence [7, 8]. It had been discovered some nonlinear regularities of certain PSF domain intensity over the first post-stroke year [7, 8]. Up to now little is known about the time course and severity of global PSF, as well as PSF certain dimensions over the second post-stroke time period
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