Poststroke angiogenesis: blood, bloom, or brood?

Abstract

Angiogenesis, the formation of new capillaries from existing blood vessels, is a naturally occurring phenomenon in adult humans, encompassing a range of normal functions from the physiological maturation of the female reproductive system to wound healing, as well as pathological functions, such as aiding unwanted tumor growth. Although ample evidence suggests that angiogenesis occurs in humans and laboratory animals after brain ischemia,1,2 it has long been debated whether angiogenesis contributes to the recovery of function after stroke and whether it can be harnessed as a therapy to treat stroke. The pro and con opinions of poststroke angiogenesis have been eloquently and pertinently discussed by Dr Greenberg, who attests to the benefit of angiogenesis and the potential for clinical application and by Drs Adamczak and Hoehn, who address the risk of angiogenesis and potential consequences in aggravating stroke progression. In light of the recent …