Abstract
The impact of 12-minute clinical death on congenital and acquired behaviors, the content of biogenic amines, the composition and size of neuronal populations in some regions of the albino rat brain were studied. It was shown that there were postresuscitative changes in emotional responsiveness and position-finding and explorative reactions and impairments in learning and memory processes, and decreases in physical endurance and algesthesia. These processes were associated with the changes in the levels of serotonin and noradrenalin in the frontal cortex of the brain, in those of dopamine and serotonin in the striatum, in some plasma biochemical parameters, and loss of neurons in the sector CA1 of the hippocampus and in the lateral sector of the cerebellum.
Highlights
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow; Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow
It was shown that there were postresuscitative changes in emotional responsiveness and position finding and explorative reactions and impairments in learning and memory processes, and decreases in physical endurance and algesthesia. These processes were associated with the changes in the levels of serotonin and noradrenalin in the frontal cortex of the brain, in those of dopamine and sero tonin in the striatum, in some plasma biochemical parameters, and loss of neurons in the sector CA1 of the hippocampus and in the lateral sector of the cerebellum
D. The use of locomotor activity as a behav ioral screen for neuronal damage following transient forebrain ischemia in gerbils
Summary
It was shown that there were postresuscitative changes in emotional responsiveness and position finding and explorative reactions and impairments in learning and memory processes, and decreases in physical endurance and algesthesia These processes were associated with the changes in the levels of serotonin and noradrenalin in the frontal cortex of the brain, in those of dopamine and sero tonin in the striatum, in some plasma biochemical parameters, and loss of neurons in the sector CA1 of the hippocampus and in the lateral sector of the cerebellum. Целью данной работы было эксперименталь ное исследование феноменологии и механизмов постреанимационных нарушений интегративной деятельности мозга с помощью комплексного изу чения врожденных и приобретенных форм пове дения, болевой чувствительности, физической выносливости, нейроморфологических, нейрохи мических и биохимических изменений у крыс самцов, перенесших 12 мин остановку сердца с «кажущимся» восстановлением неврологичес кого статуса
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