Abstract
Background: To examine the difference in the survival of patients with recurrent ovarian cancer who received fertility-sparing surgery (FSS) and those receiving radical surgery. Methods: Clinicopathologic data on a total of 90 patients with stage I recurrent ovarian cancer collected under the central pathological review system were subjected to survival analyses. Patients were divided into 2 groups: 1) FSS (N = 11), 2) Radical (N = 79). Results: Five-year overall survival rates of patients in the two groups were as follows: 40.8% (FSS)/44.2% (Radical), respectively. There was no significant difference in overall survival among the groups (P = 0.887). Additionally, three-year postrecurrence survival rates of patients in the two groups were 24.8% (FSS) and 25.3% (Radical) (P = 0.730). Furthermore, we accumulated 137 patients {FSS (N = 58), Radical group (N = 79)} with stage I recurrent ovarian cancer from the current study and six representative reports in the literature. Patients who experienced recurrence in the remaining ovary alone (FSS) showed a more favorable prognosis than those who had extra-ovarian site recurrence (overall survival: P = 0.021, postrecurrence survival: P = 0.069). Conclusions: Although our retrospective analysis was very preliminary, we could propose the hypothesis that patients with stage I recurrent ovarian cancer who undergo FSS may not show poorer survival rates than patients who receive radical surgery.
Highlights
In the Cancer Statistics of 2008, it was estimated that 225,900 women were diagnosed with epithelial ovarian cancer (EOC), and 140,200 died of the disease worldwide [1]
Conclusions: our retrospective analysis was very preliminary, we could propose the hypothesis that patients with stage I recurrent ovarian cancer who undergo fertility-sparing surgery (FSS) may not show poorer survival rates than patients who receive radical surgery
In accumulating patients from the current study and previous literature, we investigated whether there was an association between the recurrence sites and clinical outcome
Summary
In the Cancer Statistics of 2008, it was estimated that 225,900 women were diagnosed with epithelial ovarian cancer (EOC), and 140,200 died of the disease worldwide [1]. In Japan, approximately 10% of women with EOC were reported to be diagnosed at childbearing age [7]. In this young generation, the preservation of reproductive and/or female endocrine functions is a crucial problem. Since most young women with early-stage EOC desire to preserve their reproductive functions, fertility-sparing surgery (FSS) has been selected in those pa-. With regard to women with recurrent EOC who have undergone FSS, there has been limited information yielding by previous studies. In an attempt to answer the above-mentioned questions, we retrospectively examined the difference in the overall and postrecurrence survival of patients with stage I recurrent EOC who had received conservative and radical surgery. The novel concept of FSS in stage I EOC patients is proposed
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