Abstract
SummaryUnderstanding how to modulate appetite in humans is key to developing successful weight loss interventions. Here, we show that postprandial glucose dips 2-3h after a meal are a better predictor of postprandial self-reported hunger and subsequent energy intake than peak glucose 0-2h and glucose iAUC 0-2h. We explore the link between postprandial glucose, appetite, and subsequent energy intake in 1070 participants from a UK discovery and US validation cohort, consuming 8,624 standardised meals followed by 71,715 ad libitum meals, using continuous glucose monitors to record postprandial glycemia. For participants eating each of the standardised meals, the average postprandial glucose dip 2-3h relative to baseline level predicts an increase in hunger 2-3h (r=0.16 P=<0.001), shorter time until next meal (r=-0.14 P=<0.001), greater energy intake 3-4h (r=0.19 P=<0.001) and greater energy intake 24h (r=0.27 P<=0.001). Results aredirectionally consistent in the US validation cohort. These data provide a quantitative assessment of the relevance of postprandial glycemia in appetite and energy intake modulation.FundingZoe Global Ltd, Wellcome Trust, NIHR.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.