Abstract
Objective: This study was designed to test the hypothesis that macrosomia in infants born to non-diabetic mothers is associated with an increased incidence of hyperinsulinemia and normal maternalglucose regulation in late pregnancy.Methods: Twenty mothers and their macrosomic infants were chosen as the study group, and 20 mothers with their appropriate-for-gestational-age infants werechosen as the control group.Results: No difference in postpartum mean hemoglobin Alc levels was observed between the mothers of macrosomic infants and those of control infants. Cordplasma C-peptide levels were significantly higher in macrosomic than in control infants.Conclusions: This study revealed that macrosomic infants of non-diabetic mothers were significantly more likely to have hyperinsulinemiathan were normal-sized infants, and this hyperinsulinemia was not caused by dysregulation in glucose metabolism.
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