Postpartum involution of mouse myometrium under conditions of acute toxic hepatosis

Abstract

The goal of the research was to study the structural processes of postpartum myometrial involution of C57Bl/6 mice in conditions of acute CCl4-induced hepatosis. The study was conducted on 60 female C57Bl/6 mice. Animals were divided into 2 groups: 1st – mice of the control group with physiological pregnancy, 2nd – pregnant mice with acute CCl4-induced hepatosis. The main mechanism of the process of postpartum involution of the myometrium of C57Bl/6 mice was clasmacytosis, that was morphologically represented by the presence of cytoplasmic conglomerates in the interstitium, and to a lesser extent myocyte apoptosis. More pronounced manifestations of the processes of involution were observed in the subserous muscle layer, smaller changes were observed in the vascular muscle layer and least of all in the subvascular (submucous) muscle layer. The myometrial involution processes in C57Bl/6 mice under conditions of acute CCl4-induced hepatosis slow down and do not end by the 10th day of the postpartum period, in contrast to mice of the control group.