Postpartum insulin resistance in lean Japanese women with gestational diabetes requiring intensive insulin therapy

Abstract

Most lean women with gestational diabetes (GDM) are at a low risk for perinatal adverse outcomes and require no insulin therapy during pregnancy. However, some lean women are associated with having macrosomic infants and thus require intensive insulin therapy. We hypothesized that lean women with GDM who required intensive insulin therapy (IIT) were associated with elevated insulin resistance but not beta-cell dysfunction compared with lean women who did not require IIT.