Postoperative Sinus Node Dysfunction in the Transplanted Heart: Impaired Automaticity but Normal Refractoriness

Abstract

We describe the use of the extrastimulus technique to define the range of sinus node (SN) effective refractoriness (SNERP) in the denervated transplanted human heart. SNERP could be successfully determined in 18 of 28 patients corresponding to 25 of 43 SN studies and ranged from 210 to 360 ms at a basic pacing cycle length of 500 ms (95 percent confidence limits: 252.5 to 296.2 ms), which is shorter than reported in the innervated native heart. Sixteen data sets in 12 patients showed normal SN function and nine sets of measurements in seven patients showed abnormal SN function (corrected SN recovery time greater than 520 ms). While recovery time was profoundly abnormal (279.7 +/- 94 vs 7,284.8 +/- 10,454, p less than 0.001), the SNERP did not differ significantly between the groups (274.3 +/- 40 vs 286 +/- 42 ms at 500 ms, p = 0.5) and was normal at a range of 220 to 340 ms even in those patients with grossly impaired SN recovery (SNERP in patients with normal SN function: 210 to 360 ms at 500 ms). This study demonstrates that SN refractoriness in the transplanted human heart is shorter than previously reported in innervated controls and suggests that posttransplantation SN dysfunction is characterized by impaired automaticity rather than impaired refractoriness.