Abstract
BackgroundThe clinical features and the pathological changes of desmoid tumors were studied to point out the key factors affecting the recurrence.MethodsThe clinical data and specimens of 56 patients who underwent desmoid tumor resection from 2003 to 2008 were reviewed. Possible clinical factors related to the postoperative recurrence were analyzed statistically. The specimens round the lesions were studied histopathologically.ResultsThe overall recurrence rate was 39.3%. The postoperative recurrence rate of the patients with negative surgical margins and no tumor invasion of the major vessels and nerves was low (P < 0.05). However, the desmoid tumors could destroy the cortical bone and invade the medullary cavity.ConclusionsDesmoid tumors were pathologically benign, which could extensively invade tissues around the lesions. The invasion of major vessels and nerves and quality of surgical margins are the key factors for the high postoperative recurrence rate.
Highlights
The clinical features and the pathological changes of desmoid tumors were studied to point out the key factors affecting the recurrence
Histological characteristics Microscopically, desmoid cells were spindle shaped or swollen to some extent caused by cell proliferation among massive collagen, small vessels, and the round edema fibrous connective tissue (Figure 2a, arrows)
We found that the small vessel and nerve branches were usually encapsulated by the tumors, which caused the outer membrane invasion of the vessel-nerve bundle
Summary
The clinical features and the pathological changes of desmoid tumors were studied to point out the key factors affecting the recurrence. Known as hard fibroma, fibromatosis, or aggressive fibromatosis, are rare soft tissue tumors. Desmoid tumors have few mitotic figures, their typical malignant features, such as a lack of distant metastatic potential, locally aggressive growth, and invasion of the surrounding tissues, make the full resection very hard. Their recurrence rate was estimated ranging from 19% to 77% [1]. In general, was the major treatment for desmoid tumors. The residue usually locates between the tumor and the normal structures
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