Post-operative pancreatitis as a predictor of post-operative pancreatic fistula in patients following pancreaticoduodenectomy

Abstract

Introduction: Post-Operative Pancreatic Fistula(POPF) remains the challenge following Pancreaticoduodenectomy(PD). Recently Post Operatve Pancreatitis(POP) has been defined which has been shown to be independent predictor of POPF in retrospective studies. Method: We Performed a prospective study where Serum Amylase of more than 80U/L on POD0 or POD1 was defined as POP following PD. The end point of the study was to see incidence of POP and its relation with POPF. Result: There were total 23 PDs. Most of the Patients had final diagnosis of ampullary carcinoma(52%). The incidence of POP and POPF was 56.5% and 60.9%. 84.6% patient who had POP developed POPF(P= 0.008). There was total seven Post Pancreatectomy Hemorrhage, two delayed gastric emptying, one chyle leak and four Mortality. However no statistical correlation could be made between POP and other pancreas specific complications and mortality. Conclusion: Though the sample size is less but POP seems to predict POPF in Patient following PDs in our study. Keywords: POP- Post Operative Pancreatitis, POPF- Post Operative Pancreatic Fistula, PD- Pancreaticoduodenctomy.