Postoperative immune function after different anesthesia methods for pediatric laparoscopic hernia repair

Abstract

Objective To investigate the effect of sevoflurane inhalation laryngeal mask airway anesthesia compared with sacral block combined with sevoflurane inhalation laryngeal mask airway anesthesia on postoperative specific cellular immune function in children with indirect hernia after laparoscopic surgery. Methods Prospectively collected 100 cases of Pediatric casts treated in Dongguan City Maternal and Child Health Hospital from January 2015 to June 2017. According to the random table method, 50 cases were divided into experimental group and control group, respectively. In the experimental group, sevoflurane was used to block the inhaled laryngeal mask with general anesthesia. The control group was treated with sevoflurane inhaled laryngeal mask. The effect of different anesthesia methods on cellular immune function in laparotomy laparoscopic surgery in two groups of children were analyzed statistically. Results The results showed that after 2 h, 24 h the levels of CD3+, CD4+, CD4+/CD8+ values in both groups were lower than those before anesthesia, but the control group decreased more significantly, the difference was statistically significant (P 0.05); the change of the CD8+ value of the two groups before and after surgery was small, the difference was not statistically significant (P>0.05). The CD3+, CD4+, CD4+/CD8+ values of the control group at 24 h after surgery were significantly lower than those of the experimental group and the difference was statistically significant (P<0.05). Compared with before anesthesia, the IL-10 levels at 24 h and 72 h after operation in the two groups were significantly increased, the differences were statistically significant (P<0.05). Conclusion Sacral block combined with sevoflurane inhalation laryngeal mask anesthesia has less influence on the specific cellular immune function after laparoscopic surgery in children with indirect inguinal hernia, and it is beneficial to the recovery of children with relatively low immune function. Key words: Indirect hernia; Child; Laparoscopes; Anesthesia, general; Immune function