Abstract
BackgroundThe controlling nutritional status (CONUT) score has been widely used to evaluate the nutritional and immunological status. Clinical value of postoperative CONUT (PoCONUT) score in hepatocellular carcinoma (HCC) remains unknown. This study assessed whether PoCONUT score could serve as a useful predictor of survival for patients with small HCC.Methods547 consecutive patients with small HCC who underwent liver resection between February 2007 and December 2015 were included in this retrospective case-control study. Patients were categorized into two groups: low PoCONUT group (PoCONUT score ≤ 2, n = 382) and high PoCONUT group (PoCONUT score ≥ 3, n = 165). Propensity score matching (PSM) analysis was applied to balance the bias in baseline characteristics. A cumulative survival curve was established by the Kaplan–Meier method, and differences in OS and RFS among CONUT score groups were determined by the log rank test. Cox proportional hazard regression analysis was used to evaluate the association of PoCONUT score and overall survival (OS) and recurrence-free survival (RFS), with calculation of hazard ratios (HRs) and 95 % confidence intervals (95 % CIs).ResultsCox proportional hazard regression analysis suggested that the PoCONUT score was an independent risk factor for both OS and RFS in patients with small HCC before and after PSM.ConclusionsHigh PoCONUT score helps to predict worse OS and RFS in patients with small HCC who underwent liver resection.
Highlights
The controlling nutritional status (CONUT) score has been widely used to evaluate the nutritional and immunological status
One of the widely used scoring systems for nutritional and immunological status is the CONUT score, which has the advantage of being readily available from three simple parameters: serum albumin concentration, total lymphocyte count and total cholesterol concentration in peripheral blood [11]
This study was designed to evaluate whether postoperative CONUT (PoCONUT) score could serve as a useful prognostic predictor for overall survival (OS) and recurrence-free survival (RFS) of patients with small hepatocellular carcinoma (HCC) who underwent liver resection
Summary
The controlling nutritional status (CONUT) score has been widely used to evaluate the nutritional and immunological status. A high preoperative CONUT (PreCONUT) score was reported to be associated with postoperative complications and with the long-term prognosis of patients with HCC who underwent liver resection [12, 13]. These studies only focus on the PreCONUT score, the clinical value of PoCONUT score, which may reflect the immunological and nutritional status after surgical removal of the tumor, is largely undefined. This study was designed to evaluate whether PoCONUT score could serve as a useful prognostic predictor for OS and RFS of patients with small HCC who underwent liver resection
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