Abstract
Data on 300 patients with early gastric carcinoma who underwent curative resection were analyzed for the suppressive effects of postoperative adjuvant chemotherapy on early recurrences. Retrospective grouping was done as follows: no chemotherapy (NC) group (169 patients), mitomycin C (MMC) group (108), and another group (23). In all, 24 patients (16 in the NC, 6 in the MMC, and 2 in the other group) who died of other diseases within 5 years after surgery were excluded. Therefore, data on 153 individuals in the NC and 102 in the MMC group were analyzed. The recurrence rate in patients with Pen A type carcinoma, with a propensity toward an early recurrence in the liver, was 37.5% in the NC and 9.1% in the MMC group. Among 27 Pen A type patients, 3- and 4-year survival was significantly higher in those receiving MMC (100%) than in those given NC (62.5%). Recurrences in the liver occurred in 6/14 of the NC patients within 3 years after surgery, whereas there were no recurrences in 11 MMC patients. Thus, the postoperative adjuvant chemotherapy with mitomycin-C has an inhibitory effect on early recurrence in patients with Pen A type early gastric carcinoma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
