Postnatally Acquired Zika

Abstract

Research Article| September 01 2019 Postnatally Acquired Zika AAP Grand Rounds (2019) 42 (3): 33. https://doi.org/10.1542/gr.42-3-33 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Postnatally Acquired Zika. AAP Grand Rounds September 2019; 42 (3): 33. https://doi.org/10.1542/gr.42-3-33 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: zika virus, zika virus infections Source: Lindsey NP, Porse CC, Potts E, et al. Postnatally acquired Zika virus disease among children, United States, 2016–2017. Clin Infect Dis. 2019 11 March [published online ahead of print]; doi: https://doi.org/10.1093/cid/ciz195Google Scholar Investigators from multiple institutions conducted a case series to describe the clinical signs and symptoms of children with postnatally acquired Zika virus disease. Cases were defined as those who met the national surveillance definition for confirmed or probable disease, had illness onset in 2016 or 2017, were reported to the national arboviral disease surveillance system, and resided in 1 of 10 participating US states. Investigators abstracted demographic, clinical, and laboratory data for each case from local health department surveillance data obtained from medical records, health care providers, and patients and guardians. Investigators grouped pediatric cases (age <18 years) into 2 age strata (1–11 and 12–17 years) and compared clinical information and outcomes between the 2 age groups by using chi-square tests. Investigators also matched each pediatric case 1:1 to an adult case (18–49 years old) by state of residence and case status (ie, confirmed or probable). Characteristics of pediatric cases were compared to those of matched adult cases by using logistic regression. There were 141 identified pediatric cases, 64% of which were in children 12–17 years old. Nearly all (N=139) acquired Zika during travel outside of the United States, with the most common countries being Mexico (N=28) and the Dominican Republic (N=26). The 4 most common signs and symptoms of Zika virus disease in children were rash (94%), fever (74%), arthralgia (48%), and conjunctivitis (36%); 18% of children had all 4 signs and symptoms. No children had neurological signs or symptoms consistent with meningitis, encephalitis, or Guillain-Barré syndrome. Significantly more children 12–17 years old had fever, arthralgia, and myalgia than did children 1–11 years old, and significantly more adults had arthralgia, arthritis, edema, and myalgia than did children. Only 1 child was hospitalized, and 20% of children were treated in the ED. No children died. The authors conclude that postnatally acquired Zika virus disease appears to be a mild illness in children that often manifests with rash, fever, and/or arthralgia. Dr Brady has disclosed no financial relationship relevant to this commentary. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device. The authors conclude that postnatally acquired Zika virus infection resembles other common viral exanthema, including rubella, measles, adenovirus, and enterovirus.1 All of these infections may be associated with maculopapular rashes. Both measles and rubella are preventable with vaccine, so asking about immunization status is important. Although postnatally acquired rubella is extremely rare,2 1,109 confirmed measles cases have been reported in the United States between January 1 and July 3, 2019.3 Some of these cases have been linked to travelers who brought measles back from countries where large measles outbreaks were occurring. A second important question to ask is where the child has traveled. In 2015, Zika virus was identified for the first... You do not currently have access to this content.