Year-end Sale % OFF 
Abstract
Early life events have been thought to contribute towards vulnerability to drug addiction later in life. In the present investigation, the effect of daily neonatal maternal isolation stress on NMDA channel activity was studied. [ 3H]MK-801 binding was measured in several brain regions from neonatally isolated (ISO) and nonhandled (NH) adult male and female rats. Maximal [ 3H]MK-801 binding in the caudate–putamen of male ISO rats was 58% higher compared to same sex NH rats. Unlike male rats, maximal [ 3H]MK-801 binding in the caudate–putamen of female ISO rats was lower than female NH rats. No other brain region showed any significant difference in maximal [ 3H]MK-801 binding between ISO and NH male and female rats, respectively. There was no effect of pup isolation on the binding affinity ( K d value) in either sex. Repeated maternal isolation is associated with alterations in the NMDA channel activity in the caudate–putamen of adult rats, and may be responsible for the augmentation in the addictive behavior reported.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
