Abstract
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases.
Highlights
In the fourth month of intrauterine life starts the trachea differentiation from the gastrointestinal tract
Myelin furnishing of nerve fibers in the bone marrow starts around the fourth month of intrauterine life, while the nerve fibers descending from upper brain cells to the spinal chord are not myelinized before expiry of one year from the birth
Test results of isolated tracheal preparations function in newborn and still-born infants are showing that acetylcholine, dopamine, histamine and serotonin applied in different concentrations (, mol/dm, μmol/dm- ) have different effect on tracheal smooth muscles
Summary
In the fourth month of intrauterine life starts the trachea differentiation from the gastrointestinal tract. In the beginning of fifth month of fetal life many nervous fibers start assuming the white appearance, a myelin deposit sheath, formed after the repeated circular movements of Schwann’s cells membrane around axon. Myelin membrane covering the nerve fibers along the spinal chord has quite different origin, as it is formed from oligodendroglial cells. Myelin furnishing of nerve fibers in the bone marrow starts around the fourth month of intrauterine life, while the nerve fibers descending from upper brain cells to the spinal chord are not myelinized before expiry of one year from the birth. For the purpose of verifying the pharmaco-physiological development of bronchial receptor system in dependence of its developmental phase, examined in this study were the effects of acethylcholine, dopamine, histamine and serotonin on isolated human trachea preparations of newborn infants in different gestation weeks, from pharmaco-pathophysiological aspect
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
