Year-end Sale % OFF 
Abstract
Studies of the ontogeny of dopamine D2 receptors in rat striatum were carried out using [ 3H]spiroperidol as ligand in the presence of 30 nM ketanserin. D2 receptors increased with age, and saturation studies indicated that this was due to an increase in receptor density ( B max) and not to a change in affinity ( K A). By 21 days of age, receptor density had reached adult levels. Hill plots indicated no cooperativity in the binding from 7 to 21 days of age. Pharmacologically, receptors at 7, 14 and 21 days of age were similar to those of adult rats, exhibiting characteristics of dopamine D2 receptors. These studies provide a basic analysis of dopamine D2 receptors in rat striatum during early postnatal development.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
