Postnatal neurochemical and behavioral perturbations in rats following prenatal consumption of high fat diet: protective effect of calcium

Abstract

Event Abstract Back to Event Postnatal neurochemical and behavioral perturbations in rats following prenatal consumption of high fat diet: protective effect of calcium Chand B. Davuljigari1* and Rajarrami R. Gottipolu1 1 Sri Venkateswara University, Department of Zoology, India In this study, we examined the protective effect of calcium supplementation against the effects of prenatal high fat (HF) diet on offspring sensory-motor maturation and neurochemistry in rats. Pregnant rats were fed with HF and control diets from GD 6 to PND 21 and stopped at weaning. Calcium was supplemented as 0.02% in drinking water to the HF diet fed dams from GD 6 to PND 21. The results showed significant changes in righting reflex, slant board behavior and forelimb hang performance in offspring of HF diet fed rats. Significant increase was observed in serum total cholesterol and triglyceride levels at PND 28, PND 60 and 3 months age groups of HF diet fed rats. HF diet fed rats also showed significant decrease in acetylcholinesterase activity and accompanied by increase in acetylcholine levels in cortex, cerebellum and hippocampus at PND 28, PND 60 and 3 months age group rats. The mitochondrial superoxide dismutase and catalase activities decreased whereas MDA levels increased in all brain regions of selected age groups of HF diet fed rats. Significant deficits were also observed in spatial learning and memory behavior in HF diet fed rats. However, supplementation of calcium reversed the HF diet-induced alterations in neurobehavioral functions. In conclusion, these data indicate that consumption of HF diet during prenatal causes perturbations in neurobehavioral functions later in life further suggesting adequate calcium intake may be beneficial in treating the HF diet-induced toxicity. Acknowledgements Supported by: Committee for aid and education in neurochemistry (CAEN), International Society for Neurochemistry (ISN), Category 1B, 2014. Keywords: Acetylcholine, Acetylcholinesterase, high fat diet, triglyceride, Serum total cholesterol Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: YIC03: Young Investigator Colloquium 3 Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Davuljigari CB and Gottipolu RR (2016). Postnatal neurochemical and behavioral perturbations in rats following prenatal consumption of high fat diet: protective effect of calcium. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00061 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Chand B Davuljigari, Sri Venkateswara University, Department of Zoology, Tirupati, Andhra Pradesh, 517502, India, drchandbasha2012@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Chand B Davuljigari Rajarrami R Gottipolu Google Chand B Davuljigari Rajarrami R Gottipolu Google Scholar Chand B Davuljigari Rajarrami R Gottipolu PubMed Chand B Davuljigari Rajarrami R Gottipolu Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.