Abstract
Adult rat pancreas contains an unusually high amount of histone H1a; H1a H1 ratio = 0.27. Histone H1a is not detectable in embryonic or newborn rat pancreas. This histone begins to appear at about 1 week postnatally and reaches the adult level about 5 weeks after birth. There is an inverse relationship between the appearance of histone H1a and DNA synthesis, as indicated by the nuclear labeling index after [ 3H]thymidine autoradiography.
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