Postnatal development of the afferent projections from the dorsomedial thalamic nucleus to the frontal cortex in mice

Abstract

The postnatal development of mediodorsal thalamic projections to the dorsomedial frontal cortex of mice was assessed by means of the retrograde peroxidase–colloidal gold complex tract tracing system. The tracer was injected into the dorsomedial frontal cortex from the day of birth (P0) to 60 days of postnatal age (P60). Since birth, a dense retrograde labeling has been found in the mediodorsal nucleus, which increased progressively from P4 to P8 and began to decrease at P10 until P13 (67.37% vs. the maximal average, P4). After P16, the mean average remains stable up to P60.