Abstract
The concentration of available cytoplasmic estradiol receptor was quantified in the postnatal hypothalamus and pituitary of male and female rats, aged from 4 to 28 days. The uterine receptor was measured in female rats. The method used was designed to avoid non-specific contamination of cytosol from very young animals by plasma proteins, especially alpha-feto-protein (AFP). In the hypothalamus, the concentration of estradiol binding sites was maximal 6 days after birth and declined until day 28 to a low constant level. In the pituitary, the estradiol receptor concentration increased from day 4 and reached a plateau at 13–14 days, whereas in the uterus, the concentration of cytoplasmic binding sites rose up to day 10–12, and then markedly decreased.
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