Abstract
It is, indeed, well known that an increase in growth hormone secretion is induced by estrogen; this happens chiefly in men, 1 as is stated in the reference cited by Dr Pont. 2 Marshall et al 3 find lower estrogenic levels in postmenopausal osteoporotic women than in postmenopausal nonosteoporotic patients. On the other hand, Riggs et al 4 do not find such a difference in the estrogenic levels among postmenopausal women with or without osteoporosis. In a recent study, 5 we have not found notable bone mass variations in women with accentuated, moderate, or light degrees of estrogenic activity evaluated by means of vaginal cytology. Short-term estrogen administration decreases the bone resorption, 6 and it is believed that this is a consequence of the protectional role that, by decreasing the parathormone activity, the estrogens play on the bone. 7-9 Long-term estrogen administration decreases the bone formation surface to one eighth of its pretreatment values. 6 Growth hormone influences
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