Abstract
An important contribution to the management of certain functional gynecologic disorders was the introduction of diethylstilbestrol (stilbestrol), and this highly estrogenic nonhormonal drug is achieving increasingly wide employment. Its indications and likewise its limitations are in general those applying to the natural estrogenic hormones, and, like the latter, its most extensive application has been in the treatment of the vasomotor symptoms of the menopause. When such symptoms are sufficiently severe to constitute a troublesome problem, the resort to estrogens, including diethylstilbestrol, is rational and the results are good. This is not the place to review the whole problem of the management of menopausal women, to emphasize that estrogenic therapy is only a part of this management or to weigh the advantages and disadvantages of diethylstilbestrol as compared with the natural estrogens, or the so-called conjugated and synthetic estrogens. The fact remains that diethylstilbestrol is extensively employed and that in most
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