Postinfectious cough and its mechanism of neurogenic inflammation

Abstract

Postinfectious cough is the most common cause of subacute cough. However,to date,the mechanism of pathogenesis is unclear and still lack of satisfactory treatment. The occurrence of cough is related to the two cough adaptors and the abnormal increase of the cough reflex sensitivity (CRS) is a very important reason of cough response. The neurogenic inflammation mediated by the neuropeptide releaseing from the sensory nerve endings (mainly C fibers terminals) may play an important role in the change of CRS and pathogenesis of postinfectious cough. Virus infection cause airway inflammation and increase the reaction to the two adaptors. Neuropeptides and Neurotransmitter can be released by a variety of mechanisms. Therefore, investigation for the pathogenesis of postinfectious cough caused by viral infection is helpful to reveal the nature of the disease and is important to better treatment. Key words: Cough; Neurokinin; Neurogenic inflammation ; Postinfectious cough