Abstract
BackgroundPrevious studies have demonstrated that ICU (intensive care unit) survivors have decreased long-term survival rates compared to the general population. However, knowledge about how to identify ICU survivors with higher risk of death and the adjustable factors associated with mortality is still lacking.Methods and DesignThe FROG-ICU (the French and European Outcome Registry in Intensive Care Units) study is a prospective, observational, multicenter cohort study where ICU survivors are followed up to one year after ICU discharge. Beside one year survival, the study is designed to assess incidence and identifying risk factors for mortality over the year following discharge from the ICU. All consecutive patients admitted in ICU to the 28 participating centers during the study period will be included. Every subject will undergo an evaluation at admission, throughout the ICU stay and at ICU discharge. The global, especially cardiovascular, assessment of each subject will be performed through a complete clinical exam, instrumental tests (electrocardiogram, echocardiogram) and biological parameters. Blood and urine samples will be collected at admission and at discharge with the primary goal to assess effectiveness of routine and novel cardiovascular, inflammatory and renal biomarkers, with potential interest in risk stratification for patients who survive an ICU stay. The follow up will include a careful tracking of patients through telephone calls and questionnaires at 3, 6 and 12 months after ICU discharge. FROG-ICU aims to identify the clinical and biological phenotype of patients with different levels of probability of death in the year after ICU discharge.DiscussionFROG-ICU has been designed to better understand long term outcome after ICU discharge as well as risk factors for all-cause and cardiovascular morbidity and associated mortality. It is a large prospective multicenter cohort with a biological (on plasma and urine) collection and one-year follow-up of ICU patients. FROG ICU will allow performing a risk stratification of ICU survivors as to recognize the subset of patients who may benefit from an early intervention to allow decreased cardiovascular morbidity and related mortality.Trial registrationClinicalTrials.gov NCT01367093.
Highlights
Previous studies have demonstrated that ICU survivors have decreased long-term survival rates compared to the general population
FROG ICU will allow performing a risk stratification of ICU survivors as to recognize the subset of patients who may benefit from an early intervention to allow decreased cardiovascular morbidity and related mortality
To reduce the mortality rate of ICU survivors, it is important to identify the group of patients who have a higher probability of death in the year following ICU discharge and to recognize the adjustable factors associated with mortality
Summary
Previous studies have demonstrated that ICU (intensive care unit) survivors have decreased long-term survival rates compared to the general population. Knowledge about how to identify ICU survivors with higher risk of death and the adjustable factors associated with mortality is still lacking. Numerous studies have been designed to investigate the early mortality of patients admitted in ICU. They focus on mortality at ICU discharge, at 28 days or/and at hospital discharge [1–3]. To reduce the mortality rate of ICU survivors, it is important to identify the group of patients who have a higher probability of death in the year following ICU discharge and to recognize the adjustable factors associated with mortality. Some studies have demonstrated that mortality rates among ICU survivors are higher compared to the general population [11–15] and that ICU stay impact on patients’ quality of life [16]. Three studies [11–13] reported a worse survival rate for the ICU patients than that for the age-matched control population in the first year after ICU discharge, they observed that after 2 to 4 years, the survival curves of the two groups became parallel
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