Abstract
Objective: Seizure-related autonomic dysregulation occurs in epilepsy patients and may contribute to Sudden Unexpected Death in Epilepsy (SUDEP). We tested how different types of seizures affect baroreflex sensitivity (BRS) and heart rate variability (HRV). We hypothesized that BRS and HRV would be reduced after bilateral convulsive seizures (BCS).Methods: We recorded blood pressure (BP), electrocardiogram (ECG) and oxygen saturation continuously in patients (n = 18) with intractable epilepsy undergoing video-EEG monitoring. A total of 23 seizures, either focal seizures (FS, n = 14) or BCS (n = 9), were analyzed from these patients. We used 5 different HRV measurements in both the time and frequency domains to study HRV in pre- and post-ictal states. We used the average frequency domain gain, computed as the average of the magnitude ratio between the systolic BP (BPsys) and the RR-interval time series, in the low-frequency (LF) band as frequency domain index of BRS in addition to the instantaneous slope between systolic BP and RR-interval satisfying spontaneous BRS criteria as a time domain index of BRS.Results: Overall, the post-ictal modulation of HRV varied across the subjects but not specifically by the type of seizures. Comparing pre- to post-ictal epochs, the LF power of BRS decreased in 8 of 9 seizures for patients with BCS; whereas following 12 of 14 FS, BRS increased. Similarly, spontaneous BRS decreased following 7 of 9 BCS. The presence or absence of oxygen desaturation was not consistent with the changes in BRS following seizures, and the HRV does not appear to be correlated with the BRS changes. These data suggest that a transient decrease in BRS and temporary loss of cardiovascular homeostatic control can follow BCS but is unlikely following FS.Significance: These findings indicate significant post-ictal autonomic dysregulation in patients with epilepsy following BCS. Further, reduced BRS following BCS, if confirmed in future studies on SUDEP cases, may indicate one quantifiable risk marker of SUDEP.
Highlights
Autonomic phenomena are well described primary manifestations of epileptic seizures [1]
We evaluated the effect of bilateral convulsive seizures (BCS) and focal seizures (FS) on autonomic drive measuring heart rate (HR), BP, Heart rate variability (HRV), and baroreflex sensitivity (BRS) for 23 epileptic seizures
We used a simple experimental design and polygraphy data obtained from epilepsy patients in the epilepsy monitoring unit (EMU) to compare the effect of BCS and FS on BP, HR, and O2 saturation in the post-ictal state
Summary
Autonomic phenomena are well described primary manifestations of epileptic seizures [1]. Impaired ictal BRS has been noted in rodent seizure models [10], similar ictal and post-ictal studies in humans are unavailable, in large part because reliable, continuous peri-ictal BP recordings are difficult to obtain in clinical practice. This is an important gap in knowledge because deviant BRS responses, those associated with hypotension [11], may help premortem identification of patients most at risk of SUDEP
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