Postextrasystolic potentiation: Regional wall motion before and after revascularization

Abstract

We evaluated the augmentation of contractility which follows an extrasystole (postextrasystolic potentiation:PESP) in patients before and after coronary revascularization surgery for angina pectoris. PESP was induced by methods which result in essentially identical loading conditions of the ventricle for the beat before the extrasystole and the beat after the extrasystole. We evaluated regional ventricular function before and after revascularization in “jeopardized” segments (supplied by a coronary vessel with significant coronary disease) and “nonjeopardized” segments (supplied by a vessel without significant disease). All coronary lesions were proximal to all three anterior or all posterior segments. Those jeopardized segments with patent grafts which had augmented with PESP improved their baseline function following revascularization. Conversely, those jeopardized segments which failed to augment with PESP decreased their basic function following revascularization. Those segments in which the grafts were occluded failed to augment with PESP after attempted revascularization. Perioperative myocardial infarction resulted in a drop in ejection fraction and a failure to augment with PESP. The nonjeopardized segments responded to PESP similarly to the ischemic augmenting segments. The results of this study suggest that PESP does detect ventricular segments which will improve basic function following revascularization. Those segments which fail to augment with PESP are most likely more ischemic than the augmenting segments, will not improve, and may even decrease function following revascularization.