Abstract
Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous platelet concentrate rich in growth factors and plasma proteins, obtained by centrifugation of patient whole blood, and widely used in oral surgery. This report describes a case of alveolar ridge preservation with L-PRF membranes. Postextractive alveolar healing was then assessed through a histologic and histomorphometric analysis. A patient requiring tooth extraction and subsequent implant rehabilitation was treated with simple extraction and socket filling with L-PRF membranes. Implant placement was performed at 3 months, and a bone biopsy was obtained for histomorphometric analysis. Histological examination of the grafted sites showed that the use of L-PRF could achieve good results in terms of bone dimension and quality and soft tissue healing. The results of this study support the use of L-PRF membranes to preserve hard and soft tissues after tooth extraction.
Highlights
Several techniques have been described in the literature to maintain alveolar bone volume after tooth extraction and facilitate subsequent restorative procedures with endosseous implants.Tooth extractions are common dental procedures used to remove decayed, damaged, or periodontally compromised teeth
A patient requiring tooth extraction and implant rehabilitation was treated with simple extraction and socket filling with Leukocyte- and platelet-rich fibrin (L-PRF) membranes
Implant placement was performed three months after ridge preservation, and a bone biopsy was obtained for histomorphometric analysis
Summary
Several techniques have been described in the literature to maintain alveolar bone volume after tooth extraction and facilitate subsequent restorative procedures with endosseous implants. L-PRF membranes are composed of a dense, high cross-linked, fibrin mesh in which are embedded platelets and leucocytes This biological scaffold releases growth factors (PDGF-AB, TGF-β, and VEGF), adhesion molecules (fibronectin, vitronectin, and thrombospondin-1), and pro- and antiinflammatory cytokines, for up to 7 days [10, 11], which modulate reparative inflammatory process; increase tissue regeneration, angiogenesis, and neovascularization; and reduce postoperative pain and edema [12]. These characteristics make L-PRF suitable as grafting material for postextraction sockets, especially considering the modest costs, simple preparation, and no risk for cross infections. The aim of this study was to report a case of postextraction socket grafted with L-PRF membranes through a clinical and radiographic evaluation after a 3-month healing period
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