Posters. P15 The presentation of papillary serous carcinoma of the endometrium in a cervical thinprep sample

Abstract

Papillary serous carcinoma of the endometrium (PSCE) is a distinct but rare type of endometrial carcinoma. It has an aggressive nature and tumours with lympho‐vascular involvement are more likely to have extra‐uterine disease and poor prognosis.1 Post menopausal bleeding (PMB) is the most common presenting symptom. A liquid‐based cervical sample was received from a 77‐year‐old female with PMB. The sample was prepared using the ThinPrep technique. The specimen was heavily blood‐stained and the initial slide showed scattered, highly abnormal cell groups, which were difficult to assess. A glacial acetic acid wash was performed to optimize the preparation. The resultant slide showed numerous highly abnormal cell groups, with enlargement, pleomorphism and abnormal chromatin pattern and were frequently arranged in papillary clusters, many with prominent nucleoli and numerous bare nuclei with background necrosis. These characteristics are consistent with previous descriptions of the cytomorphology of PSCE in conventional cervical smears.2 The cervical biopsy and endometrial currettings showed the presence of high‐grade PSCE. Follow‐up peritoneal washings showed a few clusters of suspicious cell groups and the hysterectomy confirmed high‐grade PSCE with cervical involvement and positive left iliac lymph nodes, which is consistent with the aggressive pattern of the disease.