Abstract
BackgroundPosterior reversible encephalopathy syndrome (PRES) is a rare neurological condition with many associated risk factors. The presentation varies and consists of seizures, impaired visual acuity or visual field deficits, disorders of consciousness, headaches, confusion and focal neurological deficits. The diagnosis relies on clinical presentation and MRI findings. Treatment and prognosis are related to the underlying etiology.Case presentationWe present a 58-year-old woman with ovarian cancer who developed symptoms and radiologic signs of PRES with no apparent trigger other than a sudden increase in blood pressure for the first time in her life and before any treatment has begun. Antibodies to collapsin response-mediator protein-5 (CRMP-5), a malignancy related paraneoplastic protein, were identified in her CSF.ConclusionsWe present a novel and intriguing association between PRES and antibodies against CRMP-5 which may highlight a new etiology for this condition.
Highlights
Posterior reversible encephalopathy syndrome (PRES) is a rare neurological condition with many associated risk factors
We present a novel and intriguing association between PRES and antibodies against collapsin response-mediator protein-5 (CRMP-5) which may highlight a new etiology for this condition
We present a woman with ovarian cancer who developed symptoms and radiologic signs of PRES prior to any treatment
Summary
Posterior reversible encephalopathy syndrome (PRES) is a rare neurological condition with many associated risk factors. Two case reports have described PRES in ovarian cancer patients [9, 10]. We present a woman with ovarian cancer who developed symptoms and radiologic signs of PRES prior to any treatment.
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