Abstract
Posterior Reversible Encephalopathy Syndrome after Paralytic Ileus during B-Cell Precursor Acute Lymphoblastic Leukemia Induction Therapy
Highlights
Posterior Reversible Encephalopathy Syndrome (PRES) has been reported as central nervous system complication during chemotherapy asparaginase, and second intrathecal tripple injection were cancelled
A 9 year-old boy diagnosed as having B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) with ETV6-AML1 fusion gene received induction chemotherapy according to Japan Pediatric Leukemia Study Group (JPLSG) B12 Standard Risk Protocol with permission from the guardians
PRES is a clinical syndrome characterized by headache, confusion, various visual abnormalities, and seizure with finding of neurological imaging indicating the existence of edema in the posterior regions of the brain
Summary
Magnetic Resonance Imaging (MRI) T2-Weighted Images (T2WI) revealed bilateral subcortical and cortical hyperintensity lesions in the occipital lobes (Figure 2a) and MR angiography showed partial vascular stenosis. Posterior Reversible Encephalopathy Syndrome (PRES) has been reported as central nervous system complication during chemotherapy asparaginase, and second intrathecal tripple injection were cancelled. He presented paralytic ileus and abdominal pain on day 19 and required pain control therapy with fentanyl administration (Figure 1).
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