Abstract
PurposeTo measure peripapillary retinal nerve fiber layer (RNFL) thickness and posterior pole retinal thickness in primary angle-closure suspects (PACS) by Spectral domain optical coherence tomography (SD-OCT) and to be compared with normal subjects.MethodsThirty five primary angle-closure suspect patients and thirty normal subjects were enrolled in this study. Peripapillary RNFL and posterior pole retinal thickness by posterior pole asymmetry analysis (PPAA) in SD-OCT were measured.ResultsNo significant difference was found in both groups on age, sex distribution, refractive error, intraocular pressure (IOP) and axial length. The PACS group exhibited significantly thinner macular retinal thickness and larger asymmetry on posterior pole region compared with the control group. Yet no significant difference of peripapillary RNFL parameters was found between PACS group and normal control group. A negative correlation was observed between the total retinal thickness on posterior pole region and age when all the PACS participants were analyzed.ConclusionsPosterior pole retinal thickness measurements obtained by Heidelberg Spectralis SD-OCT using PPAA showed significant thinner change in PACS group than healthy controls. Only age seemed to be an indicator in the occurrence of glaucomatous damage in PACS patients.
Highlights
Glaucoma is one of the main causes of eye blindness in the world [1]
Primary angle-closure disease (PACD) is made up three types: primary angle-closure suspect (PACS), primary angle-closure glaucoma (PACG) and primary angle closure (PAC) as well [5, 6]
A negative correlation was observed between the total retinal thickness on posterior pole region and age when all the PACS participants were analyzed (r = − 0.487, p = 0.006)
Summary
Glaucoma is one of the main causes of eye blindness in the world [1]. In Asia, the most common type of glaucoma is primary angle-closure glaucoma (PACG) [2, 3]. Primary angle-closure disease (PACD) causes half of glaucoma-induced blindness [4]. PACD is made up three types: primary angle-closure suspect (PACS), PACG and primary angle closure (PAC) as well [5, 6]. Study has showed that about 22% of PACS could be developed to PAC and 28% of the latter advanced to PACG [6, 7]. Since visual field is found defected only after 40–50% of RGCs has lost, it is hard to diagnose the glaucoma early by visual field
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