Poster - Thurs Eve-41: Imaging and radiation delivery in helical tomotherapy: Phantom study of a moving target.

Abstract

Treating lung cancer with radiation therapy by guaranteed delivery of the prescription dose to the target is difficult due to tumour motion. The standard approach to account for motion effects consists of adding a substantial margin to a lesion visible on the CT study. Larger irradiated volume results in increased dose deposition in healthy lung and the potential for patient complications. This investigation focuses on determining the optimal choice of planning CT mode for improved radiation delivery in terms of better target coverage and sparing of healthy organs. Dosimetric measurements were performed on a helical tomotherapy unit. A Quasar® (Modus Medical Devices, London, ON) respiratory phantom was imaged while a polystyrene target moved sinusoidally with a period of 4 s and amplitude of 2 cm. For target moving in superior-inferior and lateral directions, conventional fast-CT image studies were created, as well as maximum intensity projection (MIP) and average intensity projection (AveIP) image studies using four-dimensional CT information. All types of CT studies were used to develop treatment plans with a prescription of 2 Gy per fraction to the target outlined according to the imaged data. Measurements of dose deposition were made in four locations within the moving target using an Exradin A1SL ion chamber. Comparing all results to the dose measured at the centre of the static phantom, the MIP plans overdose the target, the fast-CT results vary from case to case, while the AveIP plans provide consistent dose distribution across the target within 2% of the normalization dose.