Poster Sessions

Abstract

Background and aim: Short-term survival after liver transplantation (LT) is very good nowadays. The aim of this study was to investigate pre-transplant host and donor risk factors for mortality within 3 months after LT. Methods: We prospectively followed the 103 adult liver allograft recipients transplanted from January to October 2013. We identified the factors that independently predicted 3 months mortality using multivariable logistic regression analysis. Results: Overall 1 and 3 months post-LT survival was 94.6% and 83.6%. Univariate analysis identified the following predictors of 3 months mortality: living donor LT (p=0.03), higher recipient age (p=0.006), lower leucocytes levels at LT (p=0.02), a higher negative difference between donor age and recipient age (p=0.02), but not MELD, MELD-sodium or donor-MELD scores at LT, diabetes mellitus, presence of refractory ascites, hepatic encephalopathy or hepatocellular carcinoma. Independent risk factors for 3 months mortality were: living donor LT (p=0.03), recipient old age (p=0.02) and low white blood count (p=0.02). A cut-off >53 years for the recipient age predicted 3 months mortality after LT with a high sensitivity 92.31% and high negative predictive value (NPV) 97.8% for a AUROC of 0.74. For an AUROC of 0.71, leucocytes ≤3110/mm3 at LT had a high specificity 91% and NPV 91% for predicting short-term post-LT mortality. Conclusion: MELD-based allocation systems did not predict 3 months post-LT mortality in our transplant program. Advanced recipient age and low white blood count should be avoided in living donor LT because of increased risk of short-term mortality after LT.