Poster Session II: Alternating orientation of the chromatic pattern VEP improves signal even in the absence of contrast adaptation.

Abstract

The visual evoked potential (VEP) to chromatic pattern reversal is greatly reduced compared to VEPs to pattern onsets. Chromatic pattern onsets produce large and stereotypical waveforms that reliably differ from standard achromatic pattern reversal VEP waveforms used in clinical applications. Rapid contrast adaptation for sustained chromatic but not transient achromatic mechanisms has been suggested as one explanation for these observations. Here we first examined changes in the magnitude of response during recordings to reversing and onset grating patterns that preferentially modulate the L-M, S, and achromatic pathways. Given the evidence for both chromatic and achromatic orientation-selective mechanisms, we then hypothesized that contrast adaptation may be reduced by changing the orientation of the pattern for each reversal or onset. VEPs were recorded for 60 s with 2 onsets/reversals per second using both fixed and alternating (horizontal/vertical) orientations. FFT amplitudes for 6-second windows did not reveal evidence of adaptation for chromatic or achromatic onsets or reversal patterns over the 60-second recording period. Despite this, alternating pattern orientation increased the signal for all chromatic but not achromatic conditions. Although alternating the orientation for reversals increased the signal, the onset responses were still larger, even for non-alternating orientations. Mechanisms other than contrast adaptation must be invoked to explain the results.