Abstract
Results: Compared with the sham group, levels of myocardial TNF-a I plasma cTn I were increased (p,0.05), Histologically ,all rats in control group showed significant (p,0.05) cardiac injury.further more all rats in control group showed significant (p,0.05) apoptosis. Both Irbesartan and simvastatin significantly counteract the increase in myocardium level of TNF-a, IL-1B,IL-6,MCP-1,MIP-1alpha,plasma cTnI & apoptotic (P , 0.05). histological analysis revealed that both Irbesartan and simvastatin markedly reduced (P , 0.05) the severity of heart injury in the rats underwent LAD ligation procedure. Conclusion: The results of the present study reveal that Irbesartan and simvastatin may ameliorate myocardial I/R injury in rats via interfering with inflammatory reactions & apoptosis which induced by I/R injury. Cardiovascular Research Supplements (2014) 103, S9–S46
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