Abstract
ObjectiveThis study aimed to evaluate if single embryo culture medium (Single-ECM) better than sequential medium (Sequential-ECM), and can it improve ongoing pregnancy rates in patients undergoing assisted reproductive technique (ART) procedures.MethodsA systematic review based on electronic searches of databases was conducted and four randomized controlled trails (RCTs) were identified as targets for data extraction and meta-analysis. The primary outcome was ongoing pregnancy rate. Secondary outcomes included clinical pregnancy and miscarriage rates. The outcomes for ongoing pregnancy rate are also demonstrated according with the moment of the embryo transfers were performed: cleavage stage (day 2/3) and/or blastocyst stage (day 5/6).ResultsGeneral results demonstrated no significant differences between Single-ECM and Sequential-ECM groups for clinical pregnancy (RR=1.09; 95%CI=0.83 - 1.44; P=0.53), ongoing pregnancy (RR=1.11; 95%CI=0.87 - 1.40; P=0.39), and miscarriage rates (RR=0.89; 95%CI=0.44 - 1.81; P=0.74). Including only RCTs in which the embryo transfer was performed at the blastocyst stage, no significant difference was found for ongoing pregnancy rate (RR=1.29; 95%CI = 0.93 - 1.78; P=0.12) between Single-ECM and Sequential-ECM groups.ConclusionThe embryo culture medium employed, Single-ECM or Sequential-ECM, does not improve ongoing pregnancy rates in patients undergoing an ART cycle.
Highlights
Oligoasthenoteratozoospermia is associated with decrease in pregnancy rate
Result(s): Bilateral testicular sperm extraction (TESE) was indicated after low cell sperm count (1x106) and failed in vitro fertilization (IVF) cycle due to embryo development halting on the third day of IVF
The objective of the present study is to evaluate the effect of uninterrupted culture of embryos up to blastocyst stage without time-lapse technology
Summary
Oligoasthenoteratozoospermia is associated with decrease in pregnancy rate. We report a successful pregnancy after assisted reproduction with use of ejaculated sperm after failed bilateral testicular sperm extraction (TESE).Case report: Patient(s): Couple with male factor infertility with severe oligoasthenoteratozoospermia: sperm count of 300.000/ml, 3% of sperm motility, 1%of sperm progressive motility with seminal processing, and progressive motility recovery rate of 100.000/ml.Intervention(s): Intracytoplasmic morphologically selected sperm injection (IMSI) with freshly ejaculated sperm retrieved after general anesthesia with intravenous doses of propofol (2.5 mg/kg) used for bilateral TESE. Main outcome measure(s): Fertilization, pregnancy, and birth after IMSI with ejaculated spermatozoa followed by failed bilateral TESE. Result(s): Bilateral TESE was indicated after low cell sperm count (1x106) and failed IVF cycle due to embryo development halting on the third day of IVF. Objective: To report the outcome of a Double Ovarian Stimulation (DOS) during the folicular and luteal phases in the same menstrual cycle of a breast cancer patient. Case report: Patient: A 41-year-old woman with breast cancer performing DOS in order to preserve fertility prior to chemotherapy. Comments: DOS during a cycle is a safe and feasible technique for attempting to preserve female fertility in emergency situations like cancer patients, before gonadotoxic chemoterapic treatment takes place. Oocyte in vitro maturation (IVM) is not considered as a well-established technique in IVF Laboratories This is due to a lower pregnancy rates published. Comments: Our finding confirmed that mosaic embryo transfer would bring a healthy offspring
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