Abstract
Introduction: Background: Catatonia is a syndrome defined by immobility, rigidity, mutism, posturing, stupor, negativism, staring, and echolalia. This syndrome is commonly associated with psychiatric disorders but can also be associated with neurologic and general medical illnesses. Catatonia can be further categorized into subtypes such as malignant catatonia (MC), a rare but fulminant and progressive type of catatonia characterized by autonomic instability. MC shares clinical and pathophysiological features with other syndromes such as Neuroleptic Malignant Syndrome (NMS). Thus, diagnosis of MC can be delayed, which increases morbidity and mortality. Furthermore, catatonia can be periodic, meaning symptoms can occur, then resolve but later return. Literature suggests that the interval time between episodes of periodic catatonia varies from 4.5 to 20 months with the average interval being 10.7 months. Current evidence supports benzodiazepines and electroconvulsive therapy (ECT) as the standard treatment for the various forms of catatonia.
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