Abstract

Objectives: Current approaches rely on imaging studies or invasive exploratory exams to confirm a copper intrauterine device (Cu-IUD) when strings are missing. However, Cu-IUD devices release measurable copper (Cu) into the reproductive tract. Our study objective was to determine whether Cu levels in cervical mucus could be used to discriminate between Cu-IUD users and nonusers.

Highlights

  • Current approaches rely on imaging studies or invasive exploratory exams to confirm a copper intrauterine device (Cu-IUD) when strings are missing

  • Our study objective was to determine whether Cu levels in cervical mucus could be used to discriminate between Cu-IUD users and nonusers

  • Using inductively coupled plasma mass spectrometry (ICPMS), we determined the concentration of Cu in cervical mucus samples and compared Cu levels between Cu-IUD users and non-users

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Summary

Objectives

To evaluate levonorgestrel plasma concentrations from 72 through 96 months in obese and non-obese women using a levonorgestrel 52 mg intrauterine system (IUS). Methods: Eligible women 16-45 years old received a levonorgestrel 52 mg IUS (Liletta R ) in a multicenter trial evaluating efficacy and safety for up to ten years. We compared levonorgestrel concentrations in obese and non-obese women at each time point from 72 through 96 months using an independent-samples t-test. Plasma levonorgestrel concentrations were lower in obese compared with non-obese subjects at all time-points: 68±31 pg/mL (n=80) vs 103±44 pg/mL (n=163) at 72 months, 69±33 pg/mL (n=64) vs 99±37 pg/mL (n=148) at 84 months, and 68±26 pg/mL (n=35) vs 95±36 pg/mL (n=101) at 96 months (p

Conclusions
Findings

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