Poster 30: Relationship between p300 and neuropsychologic test performance during early recovery from traumatic brain injury

Abstract

Objective: To examine the relationship between P300 latency and amplitude and neuropsychologic test scores in persons with traumatic brain injury (TBI) during acute inpatient rehabilitation. Design: Prospective, consecutive sample. Setting: Traumatic Brain Injury Model Systems (TBIMS) acute inpatient rehabilitation center. Participants: 52 patients with TBI were evaluated using a standardized neuropsychologic battery and P300 classical oddball paradigm after obtaining 2 consecutive Galveston Orientation and Amnesia Test scores within the target range. Data of 27 patients (age, 33±15y; admission Glasgow Coma Scale score, 8.0±3.9) satisfied electrophysiologic criteria (at least 20 correct rare responses) and were further analyzed. Interventions: Not applicable. Main Outcome Measures: Standard TBIMS neuropsychologic test battery and P300 latencies and amplitudes. Results: As expected, analyses revealed significant associations between Cz and Pz amplitudes and neuropsychologic measures of sustained attention (Symbol Digit Modalities Test, Trail-Making Test). However, relationships between Cz and Pz latencies and neuropsychologic test performance were less evident. Conclusions: During early recovery from TBI, P300 amplitudes more than latencies reflect cognitive processes associated with speed of information processing and attention.