Poster 173: Expression of Osteoclastogenesis Related Factors in Oral Implant Patients

Abstract

Statement of the ProblemBone resorption is the unique function of the osteoclast cell. The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, osteoprotegerin and interleukines. According to integrin-mediated signals, the osteoclast develops a specialized cytoskeleton that permits it to establish an isolated microenvironment between itself and bone, wherein matrix degradation occurs by a process that involves proton transport.Materials and MethodsThe expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 were evaluated in order to study the correlations between implanted dental teeth and the adjacent teeth. The exudate of the gingival crevice was acquired from the dental implants, the adjacent teeth, the opposite teeth and the contralateral teeth of 24 patients.Method of Data Analysisn/aResults1The expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 in the dental implant teeth were higher than those of the contralateral teeth.2IL-1α revealed a higher expression level in the adjacent teeth than in the dental implant teeth.3The dental implant teeth and adjacent teeth did not show any remarkable difference in the expression of IL-1β.4All the other cytokines were more highly expressed in the dental implants than in the adjacent teeth.ConclusionFrom these results it might be inferred that there might be close correlation between dental implant teeth and the adjacent teeth for the expressions of the cytokines that affect the development and regulation of osteoclasts. Statement of the ProblemBone resorption is the unique function of the osteoclast cell. The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, osteoprotegerin and interleukines. According to integrin-mediated signals, the osteoclast develops a specialized cytoskeleton that permits it to establish an isolated microenvironment between itself and bone, wherein matrix degradation occurs by a process that involves proton transport. Bone resorption is the unique function of the osteoclast cell. The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, osteoprotegerin and interleukines. According to integrin-mediated signals, the osteoclast develops a specialized cytoskeleton that permits it to establish an isolated microenvironment between itself and bone, wherein matrix degradation occurs by a process that involves proton transport. Materials and MethodsThe expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 were evaluated in order to study the correlations between implanted dental teeth and the adjacent teeth. The exudate of the gingival crevice was acquired from the dental implants, the adjacent teeth, the opposite teeth and the contralateral teeth of 24 patients. The expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 were evaluated in order to study the correlations between implanted dental teeth and the adjacent teeth. The exudate of the gingival crevice was acquired from the dental implants, the adjacent teeth, the opposite teeth and the contralateral teeth of 24 patients. Method of Data Analysisn/a n/a Results1The expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 in the dental implant teeth were higher than those of the contralateral teeth.2IL-1α revealed a higher expression level in the adjacent teeth than in the dental implant teeth.3The dental implant teeth and adjacent teeth did not show any remarkable difference in the expression of IL-1β.4All the other cytokines were more highly expressed in the dental implants than in the adjacent teeth. 1The expression levels of IL-1α, IL-1β, IL-6, OPG and PGE2 in the dental implant teeth were higher than those of the contralateral teeth.2IL-1α revealed a higher expression level in the adjacent teeth than in the dental implant teeth.3The dental implant teeth and adjacent teeth did not show any remarkable difference in the expression of IL-1β.4All the other cytokines were more highly expressed in the dental implants than in the adjacent teeth. ConclusionFrom these results it might be inferred that there might be close correlation between dental implant teeth and the adjacent teeth for the expressions of the cytokines that affect the development and regulation of osteoclasts. From these results it might be inferred that there might be close correlation between dental implant teeth and the adjacent teeth for the expressions of the cytokines that affect the development and regulation of osteoclasts.