Poster 014: Interferon Alpha Therapy for Aggressive Juvenile Ossifying Fibroma

Abstract

Purpose: Juvenile ossifying fibroma (JOF) is a rare mesenchymal cell tumor with aggressive characteristics affecting persons younger than 15 years. A successful therapeutic approach to these aggressive craniofacial tumors is frequently problematic, as they often present with significant anatomic destruction, requiring extensive and occasionally debilitating resection. In addition, they are associated with a high incidence of recurrence. While the exact mechanism of action of interferon remains to be fully elucidated, it has been shown to cause osteoblastic differentiation.